Vividion Therapeutics starts Period I medical demo in innovative strong tumors with KEAP1 activator

Vividion Therapeutics starts Period I medical demo in innovative strong tumors with KEAP1 activator

Berlin, Germany, San Diego, CA, Usa, September 18, 2023 – Vividion Therapeutics, Inc. (Vividion), declared today that it has initiated dosing of individuals in a Section I oncology scientific trial of its investigational oral Kelch-like ECH Linked Protein 1 (KEAP1) activator, VVD-130037. Vividion is a biopharmaceutical enterprise using novel discovery systems to unlock high price, customarily undruggable targets with precision therapeutics for devastating cancers and immune problems, and a wholly owned and independently operated subsidiary of Bayer AG. The start of the demo represents a main milestone for Vividion’s ground breaking chemoproteomics platform.

“The initiation and dosing of this medical demo marks a major inflection place for Vividion as we advance to a medical stage enterprise. We are proud of the progress we have built in a relatively short amount of money of time with our novel pipeline of earlier undruggable protein targets for notable oncology and immunology diseases,” said Aleksandra Rizo M.D., Ph.D., Main Executive Officer of Vividion. “We are energized by the future, as we get the job done to supply multiple plans to the clinic starting in 2023.”

“We are leveraging Vividion’s innovative chemoproteomics technological innovation to establish new therapies with the opportunity to end or reverse the progression of conditions,” claimed Christian Rommel, Ph.D., Member of the Executive Committee of Bayer’s Prescription drugs Division and Head of Investigation and Improvement. “For tens of millions of patients and their families, most cancers continues to be a devastating illness, and new treatment options are desired to handle essential drivers of tumor mobile survival and expansion. The start off of Vividion’s very first scientific demo usually takes us a phase closer to a most likely meaningful new oncology procedure for a variety of varieties of cancer.”

Vividion’s proprietary chemoproteomic technique, which makes it possible for the firm to unlock significant price, traditionally undruggable focus on biology with precision therapeutics for cancers and immune problems, has been thriving following the company’s acquisition by Bayer in August 2021. The transaction allows Vividion to function at arm’s duration in a ideal-of-equally-worlds’ design, preserving its innovative, entrepreneurial lifestyle when also leveraging Bayer’s deep experience in smaller molecule development, world-wide capabilities and monetary energy.

“We are thrilled to announce the initiation and dosing of Vividion’s 1st drug in clinical progress from our chemoproteomic platform,” stated Jenna Goldberg, M.D., Chief Clinical Officer of Vividion. “This is a initial-in-course medical candidate, aimed to focus on cancers with activation of the KEAP1-NRF2 pathway. This would be a novel possibility in most cancers treatment.”

The organization is advancing a number of novel biology systems toward the clinic and has far more than a dozen very similar pipeline alternatives rising in early discovery in the fields of oncology and immunology. The Stage I scientific trial will appraise the basic safety, pharmacokinetics and pharmacodynamics and preliminary efficacy of VVD-130037 in individuals with state-of-the-art sound tumors. Demo contributors will have a histologically confirmed metastatic or unresectable strong tumor. Members will obtain ascending doses of VVD-130037, orally, as soon as day-to-day in 21-working day treatment method cycles.

About Vividion
Vividion Therapeutics, Inc. a wholly owned and independently operated subsidiary of Bayer AG acquired in August 2021, is a biopharmaceutical corporation utilizing novel discovery technologies to unlock significant value, customarily undruggable targets with precision therapeutics for devastating cancers and immune conditions. The company’s platform has enabled it to establish hundreds of formerly unidentified functional pockets on perfectly-validated protein targets implicated in a large variety of conditions, although simultaneously figuring out compounds from its proprietary covalent chemistry library that interact in a highly selective manner with those pockets. The company is leveraging its proprietary chemoproteomic system to advance a diversified pipeline of extremely selective tiny molecule therapeutics targeting high benefit, customarily undruggable targets in oncology and immunology. For far more information and facts, make sure you pay a visit to www.vividion.com.

About Bayer
Bayer is a international business with main competencies in the daily life science fields of well being care and nourishment. Its products and solutions and products and services are intended to aid people and the world thrive by supporting endeavours to grasp the key challenges offered by a escalating and getting old world-wide population. Bayer is dedicated to driving sustainable enhancement and creating a good effects with its firms. At the identical time, the Team aims to improve its earning electrical power and develop benefit through innovation and development. The Bayer brand stands for belief, reliability and high quality through the planet. In fiscal 2022, the Group employed close to 101,000 men and women and had income of 50.seven billion euros. R&D bills in advance of distinctive objects amounted to 6.2 billion euros. For extra data, go to www.bayer.com.

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Forward-Looking Statements
This launch could consist of forward-seeking statements dependent on present assumptions and forecasts designed by Bayer administration. Different identified and mysterious threats, uncertainties and other factors could guide to substance differences concerning the precise potential success, financial condition, progress or effectiveness of the company and the estimates presented below. These aspects involve all those talked about in Bayer’s public stories which are offered on the Bayer web site at www.bayer.com. The organization assumes no liability in any respect to update these ahead-seeking statements or to conform them to future activities or developments.

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