Mind Iron Accumulates With Put up-Traumatic Headache

Mind Iron Accumulates With Put up-Traumatic Headache

Healthy living

Healthy living — Results may level to novel biomarker

by Judy GeorgeDeputy Managing Editor, MedPage Now

Mind iron accumulated in folks with acute write-up-traumatic headache, an imaging examine showed.

Higher levels of iron based mostly on T2* sign modifications had been observed in article-traumatic headache individuals relative to healthful controls, according to Simona Nikolova, PhD, of the Mayo Clinic in Phoenix, and co-authors.

Optimistic correlations emerged between iron accumulation — a marker of neural injuries — and headache frequency, time considering the fact that mild traumatic mind harm, and the amount of life span gentle traumatic mind accidents, the scientists reported in an abstract produced forward of the American Academy of Neurology (AAN) yearly conference.

Headache is a widespread grievance following traumatic mind injury. The most prevalent post-traumatic headache phenotypes are migraine-like headache and tension-type-like headache.

In much more than fifty percent of individuals with acute post-traumatic headache, head discomfort resolves normally over time. Clinicians are not able to predict which clients with acute put up-traumatic headache will have pain that resolves, even so, and which will have persistent head pain.

“These benefits advise that iron accumulation in the brain can be applied as a biomarker for concussion and publish-traumatic headache, which could probably enable us have an understanding of the fundamental procedures that come about with these problems,” Nikolova stated.

The researchers assessed sixty people today who had write-up-traumatic headache because of to mild traumatic brain injury and sixty age-matched balanced controls. All members experienced 3T mind MRI with T2* mapping. T2* differences had been identified using age-matched paired t-tests.

In the write-up-traumatic headache team, most gentle traumatic brain accidents had been because of to a drop (45%), motor car or truck accident (30%), or a fight (twelve%). Other causes incorporated hitting the head against an object or sports activities injuries. In general, 46% experienced one particular delicate traumatic mind damage in their life time, seventeen% had two, sixteen% experienced 3, five% experienced four, and 16% had 5 or much more.

In put up-traumatic headache individuals, lower T2* values were being found in the correct supramarginal space, left occipital, bilateral precuneus, right cuneus, right cerebellum, correct temporal, bilateral caudate, genu of the corpus callosum, suitable anterior cingulate cortex, and ideal rolandic operculum (P<0.001).

Positive correlations emerged between lifetime mild traumatic brain injuries and iron accumulation in the right gyrus rectus and right putamen, the researchers said. Likewise, a relationship was seen between the time since the most recent mild traumatic brain injury and T2* signals in the bilateral temporal, right hippocampus, posterior and superior corona radiata, bilateral thalamus, right precuneus and cuneus, right lingual, and right cerebellum.

Headache frequency also was tied to T2* signals in the posterior corona radiata, bilateral temporal, right frontal, bilateral supplemental motor area, left fusiform, right hippocampus, sagittal striatum, and left cerebellum.

“Previous studies have shown that iron accumulation can affect how areas of the brain interact with each other,” Nikolova said. “This research may help us better understand how the brain responds and recovers from concussion.”

Because the study used an indirect measure of iron burden, it’s possible the findings may be influenced by other factors like hemorrhage or changes in tissue water rather than iron accumulation, she noted.

  • Judy George covers neurology and neuroscience news for MedPage Today, writing about brain aging, Alzheimer’s, dementia, MS, rare diseases, epilepsy, autism, headache, stroke, Parkinson’s, ALS, concussion, CTE, sleep, pain, and more. Follow


The study was supported by the U.S. Department of Defense and the National Institutes of Health.

Nikolova had nothing to disclose. Co-authors reported relationships with industry, publishing companies, and nonprofit organizations.

Primary Source

American Academy of Neurology

Source Reference: Nikolova S, et al “Brain iron accumulation in participants with acute post-traumatic headache” AAN 2024 Abstract S20.007.

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